Wednesday, February 29, 2012

Weight-loss Seriously Isn't Weight Loss, What's the Difference ...

February 29, 2012

Tags: online loan, payday loan

Quite a few people who find themselves want to lose weight don?t result in the variation involving weight-loss and weight reduction. A large mistake, considering weight-loss and weight reduction will not be similar phrases. Belief that you have a significant contrast between weight-loss and weight reduction typically potential customers people to health and fitness frustration and stagnation. In order to actually obtain your maximum shape and wellness, you need to have an effective idea of how almost everything is proven to work how about we you must do acquiring a far better idea of the visible difference involving losing weight and losing fat.

Fat loss is just not regarding how lots of lbs you get rid of, simply how much you weigh within the degree-weight reduction is concerning eliminating excess weight and inches wide fast payday loan the best places whilst a fantastic lean muscle. Weight-loss, however, generally is no more than simply how much you weigh. This doesn?t caution about whether or not one?s body weight is made up of fat or lean muscle-precisely the lbs depend.

The greatest crimson herring in health and fitness is definitely the volumes within the degree. Excess fat is just not what is your health and fitness. Muscle tissues weigh over fat, so many times you may have got a cheaper weight but nonetheless search unattractive and not healthy. Quite a few heroes vi download torrents concentration completely on the weight as a sign with their health and fitness success and turn exasperated how they usually are not shopping much better even as their lbs decrease. Some people halt being focused on body building size (what?s right to accomplish) simply because they note that their lbs intend up.

Both click the ways to health and fitness already mentioned betray the truth that lots of individuals don?t appreciate how their own health operate. One?s body has two stores that this ways to use strength: fat and lean muscle. If your calories goes down, one?s body picks one of these stores to use for strength. Models attempting to build muscle by way of health and fitness, one?s body will try the posterior tibial muscle stores for strength leave you saddled with unwanted weight. Unwanted fat weighs in at lower than lean muscle and so burning off lean muscle implies that you can weigh a smaller amount, but nonetheless have that bothersome abdominal overhang.

The way to successfully lose weight, loose fat and keep the muscle is actually incorporating a healthy diet plan with frequent exercise. Crash dieting is the ideal recipe ingredients for fat devastation-without worrying about work out it deserves, one?s body will take at a distance in your lean muscle for strength leave you saddled with flab (and aggravated further than notion). Really don?t ?cheat? by crash dieting or getting weight loss pills. Lose weight the wholesome way by exercising, the right diet and finding out how one?s body functions avoid unwanted weight that wont disappear completely.

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Source: http://flashplayground.com/weight-loss-seriously-isnt-weight-loss-whats-the-difference/

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Whole Foods Thinks Kinect-Powered, Automated Shopping Carts Are the Future [Video]

In a bid to use modern technology to recreate a dream of the 1970s, Whole Food has developed a shopping cart which uses Kinect and a tablet to follow you round the store and monitor what you buy. But who really cares? More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/uBH92ODjqjk/wholefoods-thinks-kinect+powered-automated-shopping-carts-are-the-future

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Colton Dixon: American Idiot on American Idol?


It's not hard to imagine Colton Dixon on Broadway, is it?

This American Idol veteran - who tried out for both previous seasons and hadn't even planned on giving it a third go until the judges convinced him during his sister's opening audition this year - covered "Decode" on last night's live audition show, leaping atop a piano to close the performance and looking like he belongs in "American Idiot" or "Rock of Ages."

That's not a diss. Just an observation. Jennifer Lopez told Colton he sings "from the heart," but she told that to pretty much every contestant last night.

Watch Dixon's performance now and decide how he compares to other season 11hopefuls such as Deandre Brackensick.

Source: http://www.thehollywoodgossip.com/2012/02/colton-dixon-american-idiot-on-american-idol/

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Tuesday, February 28, 2012

Internet Marketing ? Make Money Online | EzinePR.com - Submit ...

Sorry, Readability was unable to parse this page for content.

Source: http://ezinepr.com/cars-trucks-cycles/reviews-automotive/internet-marketing-make-money-online/?utm_source=rss&utm_medium=rss&utm_campaign=internet-marketing-make-money-online

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Are Rich People Less Moral?

What does morality have to do with driving and traffic tickets?

Most of the time it has nothing to do with a desire to cheat, steal, or harm another person. It could just be ignorance and bad driving habits. You could be a great driver and habitually speed 5-10 mph above the limit. That is not, in of itself, a sign of sociopathic behavior. Cutting people off and trying to run them off the road *is*.

Parking tickets are a better indicator. I personally know of some people that are not anything close to rich, but have a ton of parking tickets. They have TV shows about the boot being put on people that act that way. If anything, that would be independent of wealth. We all have experienced those assholes who cannot part for shit. You know the type. Those that literally park with no regard to anyone else, if they are even lined up the spot correctly, or blocking somebody else.

Making a ticket proportional to wealth is just discrimination. I hate it when people just want to penalize the rich for "being" rich. It's stupid and disingenuous to the debate over traffic safety.

You really want change? Eliminate the financial penalty entirely. Mandate that every ticket is a minimum 10 hours of community service picking up trash, visiting senior citizens, meals on wheels, whatever. If the minimum was an entire days worth of work on the weekend that benefited the community traffic violations would plummet. We can't do that because we built an entire financial infrastructure out of people breaking laws and being fined . All that encouraged was greater fines, gaming of the system (fucking with orange lights to increase running reds), and new laws to increase revenue.

My grandfather was a traffic cop who barely wrote any tickets. Towards the end of his career he was catching hell because he was not meeting his quota. He would actually give warnings and talk to people to explain why it was dangerous. Can't have that.

As for the study, I think it is incredibly stupid to say, "the rich" are more immoral. While it is true that the rich are less affected by most penalties, a more accurate statement would be that our current environment financially rewards those who act like douchnozzles to the rest of us. Large scale sociopathic behavior has so many legal loop holes that it is readily apparent that the whole game is rigged.

Those that act with honor, give back to their communities, are penalized and have to work that much harder in business to compete. It takes sacrifice, financial sacrifice, to operate a company that refuses to outsource, screw employees over, and actually work to the benefit of society instead of just giving lip service.

There are plenty of rich people that are complete sociopaths, but I also know quite a few that are genuinely nice people that care. There is nothing about the state of being wealthy that induces immoral behavior. Immoral behavior exists independently. It's the regulations and tax laws that allow immoral people to attain wealth easier.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/C-vws0O6S4A/are-rich-people-less-moral

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Eye-tracking reveals variability in successful social strategies for children with autism

Eye-tracking reveals variability in successful social strategies for children with autism [ Back to EurekAlert! ] Public release date: 27-Feb-2012
[ | E-mail | Share Share ]

Contact: Mary Billingsley
mbillingsley@jaacap.org
202-966-7300 x105
Elsevier

Eye-tracking reveals variability in successful social strategies for children with autism spectrum disorders: Reports new study in Journal of the American Academy of Child and Adolescent Psychiatry

Washington D.C., February 27, 2012 In a study published in the March 2012 issue of the Journal of the American Academy of Child and Adolescent Psychiatry, Katherine Rice and colleagues, from the Marcus Autism Center, Children's Healthcare of Atlanta, and Emory University School of Medicine, used eye-tracking technology to measure the relationship between cognitive and social disability in children with autism spectrum disorders (ASD) and the ability of children with ASD to pay attention to social interactions.

The study is the largest to date to observe children with ASD watching scenes of social interaction; 135 children, 109 with ASD and 26 without, all approximately 10 years old, participated. The children were shown movie scenes of school-age children in age-appropriate social situations. One set of analyses focused on the differences between children with ASD and typically-developing children, by closely matching a subset of those with ASD to typically-developing peers on IQ, gender, and age. A second set of analyses focused on measures that quantify the broad spectrum of adaptive and maladaptive behavior in ASD by analyzing variation across all 109 ASD participants.

Results indicated that children with ASD were less likely than typically-developing peers to look at other people's eyes and faces, and were more likely to fixate on bodies and inanimate objects. The results also revealed the varying ways in which children with ASD use the information they observe. For the entire group of children with ASD, increased observation of inanimate objects rather than people was associated with more severe social disability. However, for some subsets of the autism spectrum, such as highly verbal children with ASD, whose verbal IQs were larger than their nonverbal IQs, increased looking at others people's mouths was associated with less disability.

"These results help us tease apart some of the vast heterogeneity of the autism spectrum," said Rice. "For some children, atypical looking patterns may be serving as a compensatory strategy; but for others, these patterns are clearly associated with maladaptive behaviors. Objective, quantitative measures of social disability help us to identify these subsets in a data-driven manner."

###

The article "Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children" by Katherine Rice, Jennifer M. Moriuchi, Warren Jones, Ami Klin, (doi:10.1016/j.jaac.2011.12.017) appears in the Journal of the American Academy of Child and Adolescent Psychiatry, Volume 51, Issue 3 (March 2012), published by Elsevier.

The study was funded by the National Institute of Mental Health.

Notes for editors

Full text of the article is available to credentialed journalists upon request; contact Mary Billingsley at +1 202 966 7300 x105 or mbillingsley@jaacap.org. Journalists wishing to interview the authors may contact Lindsay Graham at + 1 404 785 6748 or Lindsay.Graham@choa.org.

About JAACAP

Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) is the official publication of the American Academy of Child and Adolescent Psychiatry. JAACAP is the leading journal focusing exclusively on today's psychiatric research and treatment of the child and adolescent. Published twelve times per year, each issue is committed to its mission of advancing the science of pediatric mental health and promoting the care of youth and their families.

The journal's purpose is to advance research, clinical practice, and theory in child and adolescent psychiatry. It is interested in manuscripts from diverse viewpoints, including genetic, epidemiological, neurobiological, cognitive, behavioral, psychodynamic, social, cultural, and economic. Studies of diagnostic reliability and validity, psychotherapeutic and psychopharmacological treatment efficacy, and mental health services effectiveness are encouraged. The journal also seeks to promote the well-being of children and families by publishing scholarly papers on such subjects as health policy, legislation, advocacy, culture and society, and service provision as they pertain to the mental health of children and families.

About Elsevier

Elsevier is a world-leading provider of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include SciVerse ScienceDirect, SciVerse Scopus, Reaxys, MD Consult and Nursing Consult, which enhance the productivity of science and health professionals, and the SciVal suite and MEDai's Pinpoint Review, which help research and health care institutions deliver better outcomes more cost-effectively.

A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group PLC, a world-leading publisher and information provider, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

Media contact
Mary Billingsley
Editorial Office JAACAP
+1 202 966 7300 x105
mbillingsley@jaacap.org


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Eye-tracking reveals variability in successful social strategies for children with autism [ Back to EurekAlert! ] Public release date: 27-Feb-2012
[ | E-mail | Share Share ]

Contact: Mary Billingsley
mbillingsley@jaacap.org
202-966-7300 x105
Elsevier

Eye-tracking reveals variability in successful social strategies for children with autism spectrum disorders: Reports new study in Journal of the American Academy of Child and Adolescent Psychiatry

Washington D.C., February 27, 2012 In a study published in the March 2012 issue of the Journal of the American Academy of Child and Adolescent Psychiatry, Katherine Rice and colleagues, from the Marcus Autism Center, Children's Healthcare of Atlanta, and Emory University School of Medicine, used eye-tracking technology to measure the relationship between cognitive and social disability in children with autism spectrum disorders (ASD) and the ability of children with ASD to pay attention to social interactions.

The study is the largest to date to observe children with ASD watching scenes of social interaction; 135 children, 109 with ASD and 26 without, all approximately 10 years old, participated. The children were shown movie scenes of school-age children in age-appropriate social situations. One set of analyses focused on the differences between children with ASD and typically-developing children, by closely matching a subset of those with ASD to typically-developing peers on IQ, gender, and age. A second set of analyses focused on measures that quantify the broad spectrum of adaptive and maladaptive behavior in ASD by analyzing variation across all 109 ASD participants.

Results indicated that children with ASD were less likely than typically-developing peers to look at other people's eyes and faces, and were more likely to fixate on bodies and inanimate objects. The results also revealed the varying ways in which children with ASD use the information they observe. For the entire group of children with ASD, increased observation of inanimate objects rather than people was associated with more severe social disability. However, for some subsets of the autism spectrum, such as highly verbal children with ASD, whose verbal IQs were larger than their nonverbal IQs, increased looking at others people's mouths was associated with less disability.

"These results help us tease apart some of the vast heterogeneity of the autism spectrum," said Rice. "For some children, atypical looking patterns may be serving as a compensatory strategy; but for others, these patterns are clearly associated with maladaptive behaviors. Objective, quantitative measures of social disability help us to identify these subsets in a data-driven manner."

###

The article "Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children" by Katherine Rice, Jennifer M. Moriuchi, Warren Jones, Ami Klin, (doi:10.1016/j.jaac.2011.12.017) appears in the Journal of the American Academy of Child and Adolescent Psychiatry, Volume 51, Issue 3 (March 2012), published by Elsevier.

The study was funded by the National Institute of Mental Health.

Notes for editors

Full text of the article is available to credentialed journalists upon request; contact Mary Billingsley at +1 202 966 7300 x105 or mbillingsley@jaacap.org. Journalists wishing to interview the authors may contact Lindsay Graham at + 1 404 785 6748 or Lindsay.Graham@choa.org.

About JAACAP

Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) is the official publication of the American Academy of Child and Adolescent Psychiatry. JAACAP is the leading journal focusing exclusively on today's psychiatric research and treatment of the child and adolescent. Published twelve times per year, each issue is committed to its mission of advancing the science of pediatric mental health and promoting the care of youth and their families.

The journal's purpose is to advance research, clinical practice, and theory in child and adolescent psychiatry. It is interested in manuscripts from diverse viewpoints, including genetic, epidemiological, neurobiological, cognitive, behavioral, psychodynamic, social, cultural, and economic. Studies of diagnostic reliability and validity, psychotherapeutic and psychopharmacological treatment efficacy, and mental health services effectiveness are encouraged. The journal also seeks to promote the well-being of children and families by publishing scholarly papers on such subjects as health policy, legislation, advocacy, culture and society, and service provision as they pertain to the mental health of children and families.

About Elsevier

Elsevier is a world-leading provider of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include SciVerse ScienceDirect, SciVerse Scopus, Reaxys, MD Consult and Nursing Consult, which enhance the productivity of science and health professionals, and the SciVal suite and MEDai's Pinpoint Review, which help research and health care institutions deliver better outcomes more cost-effectively.

A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group PLC, a world-leading publisher and information provider, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

Media contact
Mary Billingsley
Editorial Office JAACAP
+1 202 966 7300 x105
mbillingsley@jaacap.org


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-02/e-erv022712.php

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Monday, February 27, 2012

Get a Online game Encounter lets start work on Xbox 360 system ...

The very idea of wagering is often a interesting and fun filled encounter. With so many types of games and game playing websites which one could you pick? A straightforward selection definitely seems to be the particular Xbox, manufactured by ?microsoft?. It does not take 2nd game gaming console and also the successor to the Xbox 360 arcade games. There are a few significant capabilities which may be built-in with Xbox 360 system Reside program that enables gamers to be able to remain competitive on-line, down load game games, game presentations, trailers, Tv programs, tunes and goes. In addition, the idea delivers region particular using third-party advertising streaming companies as an example Blockbuster online. The particular Xbox was released upon Might Twelve, 2005 with the gaming console selling out and about right away about release. There are two options obtainable: Arcade and Top notch.

Xbox Arcade

The particular Xbox Arcade is the basic with the common game gaming console. It turned out introduced within March 2007 and features a wi-fi control, upvc composite Audio-video cable, High-definition multimedia interface One particular.A couple of output, an inside 412 MB recollection chips plus a a few Reside Arcade games: Rate of growth Rate of growth Catapult, Serving Frenzy, Luxor A couple of, Pac-Man Championship Release, and Uno using one hard drive. In addition, you may receive a pleasant video clip and many game trailers.

The particular Xbox Closing Fantasy

The particular Xbox Closing Fantasy XIII Exclusive edition Bundle will influence create for your full enjoyment encounter. This special offer consists of Closing Fantasy XIII, a pair of wi-fi remote controls, 250GB disk drive, the sent bluetooth headset, Ethernet cable plus a common description upvc composite Audio-video cable. Challenging push makes it possible for gamers in order to save their games together with Tv programs, videos, tunes, photographs, trailers along with other written content. You?ll be able to take advantage of the greatest selection associated with game titles, watch HD videos and TV symptoms via Minecraft Texture Maps which includes games streamed instantaneously from Blockbuster online. You?ll find a variety of add-ons also which includes music, roadmaps, quantities and personas. Along with your bluetooth headset it will be possible to chat although taking part in the sport and send speech messages to be able to friends upon Xbox 360 system Are living.

Xbox Top notch

Xbox Top notch consists of golf balls and features a control and bluetooth headset which match the particular bodies dark finish. The particular Top notch was released within April 2007 and it is considered full enjoyment in a single field. You?ll be able to watch HD videos and TV symptoms in the media of your mouse. It?s also possible to watch free movies online streamed from Blockbuster online! There may be lots of enjoyable obtainable by downloading far more music, roadmaps, quantities and personas. Aside from the nice dark gaming console, in addition, you may get yourself a wi-fi control, upvc composite Audio-video cable, dark bluetooth headset, Ethernet cable and Xbox 360 system Are living regular membership. This bundle is a great value therefore you get to get pleasure from above Three hundred sixty games games supported by Xbox.

Should you be looking for additional, then you can definitely up grade to the Xbox 300 Gigabyte Top notch. You?re going to get a much more substantial disk drive together with a pair of wi-fi remote controls upon specific restricted editions together with exclusive downloadable items.

Xbox Refurbished

Why pay more income when you can finally choose the Xbox Refurbished for no more plus a easy way to begin to do game titles and for introducing a great inclusion gaming console to the loved ones. You?re going to get the modern gaming console, high definition video clip, Film play, electronic tunes, images, an internet-based on the web connectivity within upon smooth, modest podium inside the Xbox. This minor, yet mighty gaming console will give you the many energy you have to enjoy your preferred game titles. You?re going to get the many extras which includes removable disk drive, a pair of wi-fi remote controls, Xbox 360 system Reside bluetooth headset, common Audio-video cabling, Ethernet cable and Xbox 360 system Reside Silver precious metal regular membership. Xbox may cater to as much as a number of wi-fi remote controls and contains about three Hardware A couple of.0 video pmachines regarding sent remote controls and for streaming your own electronic advertising from cameras, Mp3?s, and then any House windows XP-based Computer. ?microsoft? have made the video-conferencing digital camera, distributed individually, that can use the machine.

Similar Posts:

Source: http://www.ecis2010.org/get-a-online-game-encounter-lets-start-work-on-xbox-360-system-an-exam/

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Spanish treasure lands after 200 years (Reuters)

[unable to retrieve full-text content]Reuters - Coins worth nearly half a billion dollars finally arrived in Spain on Saturday after lying in a sunken warship for more than 200 years and following a five-year legal battle between the Spanish government and a salvage company.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/nm/20120225/wl_nm/us_spain_usa_shipwreck

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Sunday's local college sports schedule

Here's a look at the local college sports calendar for Feb. 26.
???
College Wrestling
???York College at Metropolitan Conference Championships in Elizabethtown, Pa., 9:30 a.m.
Men's College Baseball
Rawlings Southern Classic
at Emory University in Atlanta, Ga.
???York College vs. Rhodes 12:30 p.m.
???York College vs. LaGrange, 4 p.m.
Women's College Lacrosse
???York College at Greensboro, 1 p.m.
???

Source: http://www.ydr.com/sports/ci_20046755?source=rss

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Sunday, February 26, 2012

A lot of facts about that nintendo wii gaming console that you should ...

That Nintendo dsi a 7th age group game techniques unit is certainly the best value games console available, just underneath $200!

It retails at about half variances the lower close Playstation 3.

To completely find the the majority in the Gaming console, you will want to commit a lot more despite the fact that. A nunchuks really are a rather attractive attribute.

Your Nunchuk Controllers are certainly not crucial however you can have them to obtain the the majority out of specified video game titles.

The nintendo wii game console zapper delivers a whole innovative grade with the nintendo wii console; that nintendo wii game console zapper is utilized by means of online games like shortcuts and so on? Nintendo wii console zapper costs all-around 20GBP. A nintendo wii console steering wheel is used meant for rushing matches like mario kart and so on? after that there?s the newest nintendo wii game console fit in panel!

Definitely a vintage and additionally an absolute must have to your nintendo wii gaming console. That nintendo wii console meet table retails all-around 70GBP; it is a must have!!! Nintendo are going to be developing a lot more equipment to your Nintendo wii console Method.

It is quite possibly conceivable to help engage in the GameCube online games over the Gaming console. That nintendo wii console comes with 512 MB intrinsic thumb remembrance, a few HARDWARE two. 0 locations, This brand is termed because Broadway and the sharp graphics chip is named when The show biz industry. This Sd card can be utilized to get a variety of objective. A Nintendo wii console works with by using confident different types of program this will help you get matches and not demand retail outlet and get all of them! The great thing within the nintendo will be that this enjoying your gaming together with gaining fit while doing so!

Jessenia Sverchek manages a retail store which promotes Wii sensor bar replacement

Source: http://list-of-directory.com/business/a-lot-of-facts-about-that-nintendo-wii-gaming-console-that-you-should-realize/

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Source: http://www.420magazine.com/forums/420-sponsor-promos/161992-zen-healing-collective-west-hollywood-california.html

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Ohio May Ban ?Secret Compartments? (Theagitator)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/204586130?client_source=feed&format=rss

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Saturday, February 25, 2012

Level Vision ? Blog Archive ? Compare Medical insurance coverage ...

To talk about the terms Group Health insurance coverage, we have to first familiarise ourselves using the concepts Insurance policies and Health insurance coverage. The arizona lowest cost health insurance to check out is what your business interest offers. Take into account that if make sure you select a strong HMO, you will still only be ready to see confident doctors in their network which were approved simply by them. However, you for a consumer, must know very well what you are venturing into, and you have to be ones own watchdog to varying degrees and be aware you get what you afford. Since probably the most important issues with health coverage is selling price, you would like in order that you receive the best quality possible, because nobody wants to pay lots of money each month should they don?t should certainly.

The cost to a health insurance can be quite expensive especially for those who are simply starting a tiny home business. Choosing a health insurance coverage is different buying a car or truck, in the fact that, the consumer knows which the engine and even transmission are usually standard, which power glass windows are non-compulsory. If you?re in an identical financial position a lot like many friends and neighbors, paying really for coverage might not be achievable. When purchasing medical insurance coverage, know prior to which options are expected the most to your family and individual. High tax decuctible health plans at the moment are offered simply by most major insurance agencies. However it?s important to pay a bill oneself and in the future claim on the insurance firm.

It can be cliche, but there is not any time for instance the present in a health coverage plan. They don?t just cover any sort of unexpected rates of emergencies but more cover program and preventive medical procedures. ?Another factor affect the expense of your company health coverage is a postcode,? observed CIO Diane Williams. Companies in The uk, for case, are very likely to find it dearer to assure their staff than suppliers in Edinburgh and Manchester. Managed treatment plans will be popular although this treatment solution offers a fabulous restricted range of doctors and even hospitals having reduced charges. But you can find one difficulty to individual health coverage. Can an agent deal with the health coverage market after the competition will get fiercer with the minute? The response to this question is simple; health insurance coverage leads generating. With tha permanent way for finding prospective client customers, the agents have to promote most of the policies door-to-door, or via calling to arbitrarily selected buyers. However, spending these many of occasion on finding customers will possibly not guarantee any sort of return because many of the consumers won?t appreciate this process. For parents tending to disabled children who will be covered under a bunch health insurance policy cover will certainly generally persist beyond this when youngsters would discontinue to qualify for a dependent, provided the parents will show which the person attention cannot assistance himself on account of mental and physical disability and they are largely based mostly on the prepare member with regard to support.

Tags: arizona cheap insurance health

Source: http://www.levelvision.com/compare-medical-insurance-coverage-quotes-be-sure-you-find-the-proper-plan-for-you/

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Flood prevention efforts reduce insurance costs for property owners

?>?Home?>?News Releases?>?Flood prevention efforts reduce insurance costs for property owners

? Feb. 23, 2012

? Contact:? Ashley Couch, Floodplain Administrator, (480) 312-4317,
? acouch@scottsdaleaz.gov



Flood prevention efforts reduce insurance costs for property owners


Scottsdale flood insurance policy holders will continue to save more than $855,000 annually thanks to the city?s flood prevention and management efforts.? The figure equates to an average savings of $99 per year for each of the 8,670 policy holders.


Scottsdale recently scored tops in the state among municipalities during a federal floodplain management audit, ranking in the top 5 percent of all U.S. cities and counties.


As a result, policy holders in designated special flood hazard areas will continue to see flood insurance premiums reduced by 20 percent. Policy holders outside special flood hazard areas will still see their premiums reduced by 5 percent.


In its audit, FEMA?s Insurance Services Office stated Scottsdale excelled in several flood control and management areas, including:

??Maintaining flood-prone areas as open space -- about five square miles of Scottsdale?s special flood hazard areas are preserved as open space
??Proactively inspecting watercourses to identify and remedy stormwater code violations
??Providing flood zone information to the public


Check out FEMA?s community rating system.

?

Source: http://www.scottsdaleaz.gov/Page13967.aspx

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Friday, February 24, 2012

Invest in Gold and Silver and Get the Best Benefits | Press Release ...

The silver and gold prices are more likely to rise in future. Therefore, this seems to be the right time to invent in silver and gold and avail the best possible returns a couple of years down the line.

Calabasas, CA: In order to acquire the right balance, growth and stability in life, people make many different investments. However, to some extent, these investments do offer a certain amount of growth, but there comes a time when there is no balance and stability at all, and this is when one would question the decisions regarding the investments made. With the present global economy facing a serious uncertainty, it will be wrong to invest money into something that is not capable of offering the right returns. Although it is risky to make investments, it does not mean one should completely refrain from doing so. What would one call the right investment then? ?Freedom Gold Group? has the answer to this.

For more than 25 years now, Freedom Gold Group has been in the business and therefore, is completely aware of the benefits one can gain by gold investments. The clients of the company include individuals who intend to expand their wealth by investing in gold and similar precious metals. The company has a highly efficient team that works towards putting into practice the conventional American values. The experts at ?Freedom Gold Group? try to understand the basic needs of their customers. They accordingly educate them and get them into a position where they can make the most appropriate investment decisions, thus enabling them to achieve their financial targets.

Gold being a globally recognized asset holds a very strong intrinsic value. This value witnesses a serious increase even when the economic environment remains unpredictable. Presently, to invest in gold or silver with the company is one of the wisest things to do, as ?Freedom Gold Group? exactly knows how to go about with the entire procedure. The company provides its investors a complete list of options that can help them gain stability, growth as well as security. At FGG, one may plan to invest into bullion bars and coins, rare investment grade coins, Certified and Circulated Investment Grade Coins and IRA / 401K Precious Metals. It is possible to trade with investment grade coins privately. No other investment offers this type of a freedom. Moreover, the site allows you to purchase silver coins and buy gold bars online at the most unimaginable price.

According to investment experts, the silver and gold prices are more likely to rise in future. Therefore, this seems to be the right time to invent in silver and gold and avail the best possible returns a couple of years down the line. ?Freedom Gold Group? is the only solution to those not sure about what kind of investment to make.

About FreedomGoldGroup.com:

Freedom Gold Group helps one make the most appropriate investment decision. The website offers gold and silver coins at the most affordable price. To invest in silver or gold is the best way to secure the life ahead.

Get the best information if you?re looking to buy gold coins and purchase silver coins. Download your FREE investor?s kit from http://www.freedomgoldgroup.com

Freedom Gold Group
5000 Parkway Calabasas
Suite 302
Calabasas, CA 91302
Tel.: 800-496-5945
Fax: 818-591-0404

Source: http://pressreleasefiles.com/?p=11761&utm_source=rss&utm_medium=rss&utm_campaign=invest-in-gold-and-silver-and-get-the-best-benefits

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Thursday, February 23, 2012

tedman catchpenny: Survival Joe | AUDREY-LYNN.INFO | Austria ...

Survival Joe | AUDREY-LYNN.INFO | Austria ? gyfsufte& ?

[unable to retrieve full-text content]It is crucial that in the event that a hurricane strikes your city Reference and Education: Survival and Emergency Joseph Parish Read More? 34) Malorie | 2011-2-12 21:11:19. Survival Kit Made From the ?Dollar Tree? Store.

Source: http://audrey-lynn.info/reviews/survival-joe.htm

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Source: http://ahmedsalem.net/276/survival-joe-audrey-lynn-info-austria-gyfsufte/

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Source: http://tedman-catchpenny.blogspot.com/2012/02/survival-joe-audrey-lynninfo-austria.html

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Will Personal Injury Lawsuits Eventually End Football?

That?s a question that several legal bloggers have been positing over the last few weeks. The concerns largely stem from studies suggesting that the long-term effects of concussion injuries (which are quite common in football players, including those at the age level of high school and younger) may be far more severe than anybody thought. This is focused around the revelation that suffering large numbers of very minor concussions (which are extremely common in football) significantly increases the long-term risk of severe brain disorders, such as Parkinson?s disease.

There have also been a few high-profile suicides committed by athletes, including a few very promising young football and hockey players. Autopsies revealed that some of these athletes suffered from chronic traumatic encephalopathy (CTE), which is a degenerative brain disorder caused by sustaining multiple concussions over a long period of time. The symptoms of this disorder include severe depression and dementia, which would partially explain the suicides.

As one might expect, there is some fear that this new information might lead to tort lawsuits, which would cost the defendants a large amount of money in judgments and settlements. It?s conceivable that several years of this could become so costly that insurance companies would stop offering liability insurance to football organizations, which would effectively prevent them from operating.

And even if the NFL manages to deflect these lawsuits, or absorb their costs, high school and college football programs may not be so lucky. If a large majority of these programs were shut down, the NFL would have a much smaller pool of new talent, which could bleed it dry in the long run.

Personally, I think that these fears about lawsuits destroying football are pretty overblown. It?s currently the most popular sport in the United States, and generates billions of dollars in economic activity. Furthermore, football players (at least at the college and professional level, where they?re adults) can be said to have assumed the risk of injury by voluntarily playing football.

However, at the high school level, the legal and moral issues become far less clear. After all, most high school students are under the legal age of consent, so it?s hard to claim that they knowingly and intelligently assumed the risk of brain injury. In most situations, a child?s parents can give consent for them. But if you assume that a child cannot make decisions with enough maturity to legally give consent for something (and that?s the assumption that underlies laws that establish an age of majority), and the risk they incur in playing football is permanent brain injury that follows them for the rest of their lives, it?s not really fair for their parents to make that decision for them, either.

Generally, however, I don?t think that football fans have anything to worry about. In fact, a few successful and costly lawsuits against football programs may actually improve its long-term prospects, as counterintuitive as that sounds.

After all, if a few football organizations were sued because some players suffered long-term brain injuries, they would probably have a good incentive to invest in better safety equipment, especially improved helmets. If this equipment significantly reduces the risk of CTE, football clubs will have far less to worry about in the lawsuit department.

Some commentators, while remaining hopeful about the future of football, raise a rather unsettling possibility: the NFL will simply use its substantial lobbying clout to persuade state legislatures to either ban lawsuits against them for CTE, or make such lawsuits so difficult for the plaintiffs that they aren?t worth the effort.

This might save football, but it?s arguably the worst possible outcome ? even worse than football being sued out of existence. If personal injury lawsuits against football organizations are effectively banned, they will have no incentive to invest in safer equipment, or improve their safety rules.

This will mean another generation of young people suffering from chronic brain injury.

Basically, that illustrates the problem with the arguments made by many advocates of ?tort reform.? We don?t face a choice between lawsuits destroying a beloved sports institution (or the entire economy), and making it impossible for victims of negligence who have suffered real injuries from receiving compensation from those injuries. But that?s how tort ?reformers? often frame the debate.

In a legal system that guards against frivolous lawsuits, the civil justice system and the litigation process can be a force for positive change. If football clubs face lawsuits over brain injures, and these lawsuits become too costly, it will be in their economic self-interest to take steps to make the sport safer, either through investments in better safety equipment, or modifying the rules of the game to minimize head injury, or both.

There is historical precedent for this, as well. In 1905, football had just established itself as a popular sport in America. As more people played the game, more players began dying from injuries sustained on the field. It got to the point that there were serious proposals in Congress and state legislatures to ban the sport altogether. President Roosevelt persuaded the NFL to change the rules to eliminate certain plays that were responsible for most of these injuries. And thus, the sport was saved.

I?m sure a lot of people complained back then that these changes destroyed the spirit of the game. But over 100 years later, the sport of football is doing just fine. I think this is simply an example of history repeating itself. Football will adapt. And, hopefully, they won?t find it necessary to make it impossible for people who have been injured to recover compensation for their injuries.

Source: http://lawblog.legalmatch.com/2012/02/22/personal-injury-lawsuits-eventually-football/

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Wednesday, February 22, 2012

Me In My Place Android 'app' doesn't do the women justice (or the photographer, either)

Me in My PlaceMe in My Place

For far more than a year now, a semi-secretive series has graced the pixels of a Tumblr blog as well as the pages of Esquire magazine. Dubbed "Me in My Place," the series was shot by "a notable photographer, who has shot portraits of many notable people," said Esquire. The man behind the camera wasn't the point, after all. (He's since been unmasked, but we're going to make you work for it, too.) It was the subjects -- the various girls next door, Manhattan (and later L.A.) style -- who made the series at hit. The tag line: "Real girls in their own place. Not too crazy and just a pinch of naughty…"

Yes, the portraits are what they are -- probably not-safe-for-work photos of "real" women in their homes, comfortable in various stages of undress. The pics are sexy and a bit raw, and that's the appeal. Not too crazy and just a pinch of naughty. 

Esquire magazine got involved, the odd actress made appearance and things, erm, took off from there. An app was promised. And now, an app has arrived.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/VqlraFAtCto/story01.htm

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Innovation in HR: Gearing for 2020 ? Fortune Institute Of ...

(A summary of HR conclave:?Innovation in HR: Gearing for 2020, held at FIIB on 4th Februrary 2012)

?While addressing the participants, as chief guest, at the HR conclave ? INNOVATIONS IN HR ? GEARING FOR 2020 organised by FIIB on 4th February 2012, Mr. Suresh Tripathi, President HR, SRF Limited, talked about paradigm shifts that might have to be addressed for gearing for 2020.? He observed that because of a boundary-less world, there is homogeneity in consumption patterns, now that every item is available in India right from a BMW car to an iPad. He emphasized on changing global economic scenario due to which, manufacturing processes were not at one place. ?Now business flows in all directions. Wherever the manufacturing costs are less, business leaders set up their units. This impacts HR mobility i.e. in the movement of work force. He felt that a round globe has become flat because of Internet and universal information access, which is called ?Globality?. This has paved the way for integration of HR models of acquiring and retaining talents. He talked about ?Demographic dividend? from which India may get benefit as 240 million young people would be added to the work force in the next 15 years. He referred to a paradigm shift from the present vertical integration to virtual integration. He gave example of ?AIRTEL? for virtual integration. He also brought out a radical concept of small fish grabbing big fish. He visualized that small businesses which are nimble, agile survive because volumes are at bottom of the pyramid. As far as loyalties and commitment to organizations are concerned there is no long term time dimension. A future employee may commit 4 hours in the morning to one organization and afternoon to some other orgnisation or to himself. Commitment is only to the extent of contracted time and deliverables. Results of such paradigm shifts would be no human touch in virtual organisations, increase in internal stress and organisations would become faceless. He predicted that HR would have to gear up itself to deal with these changes.

In his keynote address Mr. B.Ram Mohan, Vice President- HR Everest Industries, talked about tomorrow?s world as a melting pot of diversity and constant mobility. According to him HR should be the navigation tool. He felt that encouraging innovation and planning ahead for future work force are essential tools for the visionary HR professional. He narrated the journey of HR from blue collar issues to the Board room. He opined that ?HR has often delimited its full flight into the wide space of operational and strategic areas by distancing itself from the supply and delivery chain of the business. ??HR is often short sighted in its vision of setting up goals for self?. He advocated that HR should come out of its self-acclaimed glory of the name tag of HR Professional, to mentally step out of the parameters of HR and really observe oneself as part of the business process to understand how to contribute best to the organization. According to him needs of talent in 2020 are ?Autonomy & Freedom?, ?Higher flexibility and work- life balance?, ?Customized career paths? , ?Transparency? , and? ?Opportunity to make a difference globally?. He mentioned that the following are some of the expectations of employers from future employees: domain knowledge, professionalism ,? high ethical standards, flexibility to cope with different business situations and adaptability, result orientation and execution ability, understand global business environment, partners in co-creating future businesses, creativity and innovation, maturity and emotional intelligence, and managing self. While visualizing future role of HR, he felt that HR should understand business, align stakeholders around a shared purpose, facilitate change in mindsets, obsessed about development and renewal of people, establish HR as a distinct profession by building appropriate competencies, attract and build a diverse workforce, including those who do not come to office and lastly in doing the above, HR should not forget its fundamental role as employee champions.

While welcoming the participants to the HR conclave, Dr.A.K.Sinha, Director of FIIB, explained about the mission, vision and values of FIIB, thanked both the chief guest and key note speaker for sparing their valuable time from their busy schedule ?to address the participants. He wished that participants would gain lot of insights from this HR Conclave about future role of HR, while it gears to prepare for 2020.

Dr.K.B.C. Saxena, Dean of FIIB? talked about Innovational approach at FIIB that is taking place now. While informing about management innovation as an integrated perspective at FIIB, he explained process innovation of environment and information with HR integration of people, skills and social behaviour. While elaborating about innovation process at FIIB, Dr. Saxena explained how education process (curriculum) dovetails the quality process (Curriculum delivery).

While introducing the HR Conclave topic, Dr.P.U.B.Rao, Chairperson of HR/OB area, dealt with the changes that took place from past to present and the future trends of HR. He felt that in future there may not be any HR department. In fact, every manager is an HR manager since managing people is everybody?s job. Dr.Rao wondered whether the task of interviewing a job seeker would be entrusted to a computer in future, because of technological advancement of mapping the thought process of a human being by computers.

In the first technical session, Mr. Shekhar Ghose, former Director- Personnel, Indian Airlines as chairperson of the session: Innovation in Human Capital Management, dealt with the definition of human capital. He talked about how globalization and advent of knowledge worker brought about the value of human capital. He elaborated on human, organizational and social capital.

Ms.Ishita Adhikari, ?till recently, Head H.R, Kuoni Business Travel, started her deliberations with the concept? of survival of the fittest and Innovation is survival ? age old theory of ?Darwin. ?? ?She revalidated this with the transition of E-Mails to the world of Google/Face book/Twitter, Walkman to i-pods, telephones to sleek i-phones and desktops with tablets, a Doordarshan with limited hours of programming to 24*7 telecast on innumerable channels, Post office & Bank FD to managing financial portfolios. She explained the journey of HR from Personnel & Admn. to Human Resource being a strategic business partner and she fees that HR is still evolving. She felt that Innovation in HR is a necessity and not a choice, because of changing environment and business scenario, demanding & well informed customers, handling a diversified workforce and constraints of cost and profitability targets.

Ms. Ishita defined Human Capital as the sum of a workforce?s skills, knowledge and experience and Human Capital Management as a strategic responsibility increasingly shared by all the organization?s leaders. A strategic approach to marshaling, managing and maintaining the human capital needed to maximize organizational performance. She shared some of the recent findings that 36% revenue spent on Human Capital (HC) Expenses but only 16% expressed anything more than a moderate understanding of RO(HC)I. Also that CEO?s see HC as a key Value Driver ? 92% link it to Customer Satisfaction, 82% link it to Profitability,72% link it to Innovation and New Product Development, 49% report that investors are beginning to ask about HC issues,23% report Boards involved in HC issues and in two years 36% expect such involvement. She shared some of her experiences in bring about innovative changes in her organisation.

Mr. Murli Dhar Shyam, Head Human Resources ? India, ATC Tower Company of India Pvt. Ltd., talked about human capital management. He emphasized on human values and culture of organizations for facing the future.

The second Technical session: Innovation in Strategic Alignment of the HR and Innovative HR Frameworks was chaired by Mr. Ashok Grover, Director, Skillscape. Mr. Grover talked about Global Talent Management Survey and shared the findings. A survey conducted by Softscape Research in 2008 interviewed more than 200 HR leaders from around the world representing a diverse collection of more than 20 industries ,evenly distributed among large enterprises (more than 5,000 employees; 54% of the sample) and small- and medium- sized organizations (100 ? 5000 employees; 46% of the sample).

Some of the survey results he shared were: (74%) Integrated talent management is mission critical. (70%) organizations with integrated talent management strategies have better financial performance. (66%)? linking learning management to other core talent functions yields stronger revenue growth,(56%)? succession planning impacts sales growth, and (52%)? increased focus on performance measurement is critical to identifying and retaining high performers. The research showed that outstanding performers typically deliver four to six times more performance than average performers. He advocated shift from a reactive to a proactive approach ? from Talent Management Process to Talent Management System.

Mr. Sumit Chaudhuri, Chairman and Managing Director, Third Millennium Business Resource Associates Pvt. Ltd., in his talk said that organizations have to strategize quite differently for different situations in different organisations at different points in time like cricketers have for test matches, one day internationals and T20s and even during a particular game.

Ms. Pritha Dutt, Consultant-HR & CSR -, Ex. Sr. Vice President Bharti Tele Ventures Ltd., while looking ahead at innovative HR frameworks, said that the recognition that business has no option but to be ?responsible?. Business Responsibility refers to the commitment of an enterprise to operate in an economically, socially and environmentally sustainable manner while balancing the interests of diverse stakeholders. She gave examples of the power of individual vs. unions in a connected world and the diversity in the workforce.

Ms.Pritha said that Leadership resides in everyone, not the traditional model of hierarchy based leadership. She mentioned that Role Descriptions and not Job Descriptions should be followed, and Talent Search to discover unique leadership for every individual. She also suggested that organizations should manage environment not people, in appraisals discuss ?what worked? not ?what did not?, understand what makes for an engaging work environment and blend life in work. She also emphasized HR leaders to think about Human Rights not just Human Resources, to be ethical and transparent, celebrate diversity, while respecting universal rights and providing career and personal fulfillment.

Dr. M.S.Rau, Executive Director, ISTD, shared his experiences as a hard core HR person for 36 years. He narrated how personnel administration has come up to be called HR.

Source: http://blog.fiib.edu.in/innovation-in-hr-gearing-for-2020/

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Marriage Counseling Orange County: Managing Change and Its ...

Change is stressful and difficult. Human beings are creatures of habit. When people want change they typically mean that they want others to adjust or they want a system or rule to be modified. People very seldom want to change themselves and even when they want it, they are often unwilling to do what it takes to bring about the transformation. This is no different in relationships. We typically want our spouses to change and of course we ourselves don't need any changes, right? Most couples who come see me when things go wrong, blame their spouses and want them to change. Most times they deny any problems of which they are accused. Today we are not going to talk about changing as people though; we are going to talk about external changes that impact our relationships.

His company wants to relocate him and she does not want to move to a different city. She wants to have children and he is not ready yet. She wants a bigger home or he wants a new car. Regardless of what the change is, we all face change, that is for certain. Change can happen to us without our consent; such as losing one's job, disability from an accident, and so forth. Change impacts our relationships whether we like it or not. Sometimes such alteration is good and sometimes it is disastrous. So how can we manage change to minimize any potential negative impact on our relationships?

1. When possible, honestly and deeply discuss the potential change with your spouse and find out how he or she feels about it.

2. If the change is optional, make the decision to change together; both spouses need to agree and take responsibility for the decision together. If things go wrong a joint decision eliminates any blame games.

3. If possible, take change slowly. Introduce the changes in steps, with time in between, to get used to the change.

4. Accept one change at a time, don't lump many changes together. Every change happening together builds on all the stress of each individual stress until it becomes overwhelming. Changing careers, moving, getting married, and having surgery all within a few months, for example, is not a good idea. If possible, stagger these changes over time.

5. Build on your strengths and accept changes in the areas which you feel confident in.

6. Make sure you are healthy and getting enough exercise before taking on any changes.

7. Be positive.

Pierre F. Steenberg, Ph.D., D.Min. is a relationship expert, a counselor, and a marriage seminar presenter. http://www.designinghearts.com/

To receive your free PDF on using Genograms to analyze your relationship please visit: http://www.designinghearts.com/

Original article

Source: http://marriagecounselingorangecounty.blogspot.com/2012/02/managing-change-and-its-effect-on-your.html

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Tuesday, February 21, 2012

Rainforest plant combats multi-resistant bacterial strains

Rainforest plant combats multi-resistant bacterial strains [ Back to EurekAlert! ] Public release date: 20-Feb-2012
[ | E-mail | Share Share ]

Contact: PhD Jes Gitz Holler
jgh@farma.ku.dk
(45) 41-59-37-32
University of Copenhagen

Aggressive infections in hospitals are an increasing health problem worldwide. The development of bacterial resistance is alarming. Now a young Danish scientist has found a natural substance in a Chilean rainforest plant that effectively supports the effect of traditional treatment with antibiotics.

PhD Jes Gitz Holler from the University of Copenhagen discovered in a research project a compound that targets a particular resistance mechanism in yellow staphylococci. The development of resistance in these specific bacteria is extremely rapid. Bacterial strains that do not respond to treatment have already been found in the USA and Greece.

"I have discovered a natural substance in a Chilean avocado plant that is active in combination treatment with traditional antibiotics. Resistant bacteria have an efflux pump in their bacterial membrane that efficiently pumps out antibiotics as soon as they have gained access. I have identified a natural substance that inhibits the pumping action, so that the bacteria's defence mechanisms are broken down and the antibiotic treatment allowed to work," explains Jes Gitz Holler.

Jes Gitz Holler gathered specimens of the plant, which comes from the Persea family, in Chile, where the Mapuche people use the leaves of the avocado plant to heal wounds. The results have been published in Journal of Microbial Chemotherapy.

Synthetic chemistry for sustainable production

The so-called MIC value is the lowest possible concentration of an antibiotic that inhibits the bacterial growth. With his compound from the medicine chest of the Mapuche people, Jes Gitz Holler can lower the MIC value by at least eight times:

"The natural compound has great potential and perhaps in the longer term can be developed into an effective drug to combat resistant staphylococci. At this time there are no products on the market that target this same efflux-inhibitor mechanism. We want to improve the active substance using synthetic chemistry in the laboratory. That will also ensure sustainable production of a potential drug while protecting rainforest plants," continues Jes Gitz Holler.

Jes Gitz Holler emphasises that a commercial product will benefit the Mapuche people. At present there is a written agreement between the Faculty of Health and Medical Sciences and the representative of the Mapuche people, Alfonso Guzmn, PhD, who helped procure the plant material.

Bacteria are winning the race

Yellow staphylococcus Staphylococcus aureus is the most common cause of infection in wounds from an operation. However, the bacteria can be the cause of many diseases, from abscesses and food poisoning to life-threatening infections such as infective endocarditis and sepsis. The bacteria have been a major problem in hospitals worldwide since the 1940s, and up to now the drug industry has managed to develop new antibiotics in step with the increasingly aggressive behaviour of the bacteria. Unfortunately, that development appears to be turning:

"For all intents and purposes, the drug industry is not pursuing research into new antibiotics. It is simply too expensive relative to possible earnings, and there is more money in drugs to treat chronic diseases such as diabetes. Therefore, the bacteria are winning the race resistance increases and treatment options are scarce. Research will have to find new paths and natural substances are one of them," emphasises Jes Gitz Holler.

###

Contact:
Jes Gitz Holler, PhD
Cell: 45-41-59-37-32



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Rainforest plant combats multi-resistant bacterial strains [ Back to EurekAlert! ] Public release date: 20-Feb-2012
[ | E-mail | Share Share ]

Contact: PhD Jes Gitz Holler
jgh@farma.ku.dk
(45) 41-59-37-32
University of Copenhagen

Aggressive infections in hospitals are an increasing health problem worldwide. The development of bacterial resistance is alarming. Now a young Danish scientist has found a natural substance in a Chilean rainforest plant that effectively supports the effect of traditional treatment with antibiotics.

PhD Jes Gitz Holler from the University of Copenhagen discovered in a research project a compound that targets a particular resistance mechanism in yellow staphylococci. The development of resistance in these specific bacteria is extremely rapid. Bacterial strains that do not respond to treatment have already been found in the USA and Greece.

"I have discovered a natural substance in a Chilean avocado plant that is active in combination treatment with traditional antibiotics. Resistant bacteria have an efflux pump in their bacterial membrane that efficiently pumps out antibiotics as soon as they have gained access. I have identified a natural substance that inhibits the pumping action, so that the bacteria's defence mechanisms are broken down and the antibiotic treatment allowed to work," explains Jes Gitz Holler.

Jes Gitz Holler gathered specimens of the plant, which comes from the Persea family, in Chile, where the Mapuche people use the leaves of the avocado plant to heal wounds. The results have been published in Journal of Microbial Chemotherapy.

Synthetic chemistry for sustainable production

The so-called MIC value is the lowest possible concentration of an antibiotic that inhibits the bacterial growth. With his compound from the medicine chest of the Mapuche people, Jes Gitz Holler can lower the MIC value by at least eight times:

"The natural compound has great potential and perhaps in the longer term can be developed into an effective drug to combat resistant staphylococci. At this time there are no products on the market that target this same efflux-inhibitor mechanism. We want to improve the active substance using synthetic chemistry in the laboratory. That will also ensure sustainable production of a potential drug while protecting rainforest plants," continues Jes Gitz Holler.

Jes Gitz Holler emphasises that a commercial product will benefit the Mapuche people. At present there is a written agreement between the Faculty of Health and Medical Sciences and the representative of the Mapuche people, Alfonso Guzmn, PhD, who helped procure the plant material.

Bacteria are winning the race

Yellow staphylococcus Staphylococcus aureus is the most common cause of infection in wounds from an operation. However, the bacteria can be the cause of many diseases, from abscesses and food poisoning to life-threatening infections such as infective endocarditis and sepsis. The bacteria have been a major problem in hospitals worldwide since the 1940s, and up to now the drug industry has managed to develop new antibiotics in step with the increasingly aggressive behaviour of the bacteria. Unfortunately, that development appears to be turning:

"For all intents and purposes, the drug industry is not pursuing research into new antibiotics. It is simply too expensive relative to possible earnings, and there is more money in drugs to treat chronic diseases such as diabetes. Therefore, the bacteria are winning the race resistance increases and treatment options are scarce. Research will have to find new paths and natural substances are one of them," emphasises Jes Gitz Holler.

###

Contact:
Jes Gitz Holler, PhD
Cell: 45-41-59-37-32



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-02/uoc-rpc021712.php

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